Symbol
Name
ID

Ep300
E1A binding protein p300
MGI:1276116

Phenotype annotations related to immune system

!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Leukemia	Recurrent upper respiratory tract infections	Accessory spleen	Polysplenia	Recurrent infections
Disease(s) Associated with EP300
Rubinstein-Taybi syndrome

Mouse Phenotypes

arteritis

increased B cell apoptosis

decreased B cell proliferation

small thymus

decreased thymocyte number

enlarged spleen

increased spleen weight

abnormal B cell differentiation

abnormal transitional stage B cell morphology

increased double-positive T cell number

decreased eosinophil cell number

decreased marginal zone B cell number

decreased B cell number

increased B cell number

decreased single-positive T cell number

increased activated T cell number

decreased lymphocyte cell number

decreased leukocyte cell number

abnormal spleen marginal zone macrophage morphology

intermingled spleen red and white pulp

increased IgG2b level

increased immunoglobulin level

enlarged lymph nodes

abnormal adaptive immunity

abnormal humoral immune response

increased susceptibility to systemic lupus erythematosus

increased anti-double stranded DNA antibody level

kidney inflammation

glomerulonephritis

Availability

Mouse Genotype

Ep300^Plt6/Ep300^Plt6

Ep300^tm1Pkb/Ep300^tm1Pkb

Ep300^tm2Pkb/Ep300^tm2Pkb
Tg(Lck-cre)548Jxm/0 (conditional)

Cd19^tm1(cre)Cgn/Cd19⁺
Ep300^tm2Reck/Ep300⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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